I use the otter box both kayaking and in my duck hunting boat. Nothing has gotten wet or damaged while stored in the box. I added some egg-crate foam for added protection.
The box was a birthday gift for my wife to keep camera etc. while kayaking dry. It a little hard for her to close but that may be a good thing as the seal is good. Won't really know until we use it in March.
I liked my first Otter box so much I got a second one. I use it for all my "can't get wet" gear when kayak camping. Ipod, phone, keys, wallet. I use a second one for all my safety gear when I'm on the ocean. Small air horn, emergancy light, signal mirror, etc.